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. 2023 Apr 4;2023:5584894. doi: 10.1155/2023/5584894

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Copyright © 2023 Shuo Zheng et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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UC-MSCs inhibit renal pyroptosis through the NLRP3/Caspase1 signaling pathway in vivo. (a–c) Representative graphs of kidney sections with immunohistochemistry staining for NLRP3, Caspase1, and IL-1β. Scale bar, 50 μm. (d, e) The protein levels of NLRP3, ASC, Caspase1, GSDMD, and IL-1β were measured by western blot in the control, DN, and DN+UC-MSC groups. (f) RT-PCR analysis of NLRP3, ASC, Caspase1, IL-1β, and IL-18 mRNA expressions in the control, DN, and DN+UC-MSC groups. Data are expressed as means ± SD. ANOVA was used for comparison among multiple groups. ^∗p < 0.05 and ^∗∗p < 0.01.