Fig. 2. Revealing a key anti-apoptotic molecule in HepG2 and HepG2^B[a]P cells.

A Schematic diagram of the biological functions of GRP75 in HCC. B The top 5 GO biological processes of GRP75 and the 50 most frequently altered neighbor interactors around it. C Triplicate qPCR and western blot analysis of the mRNA and protein levels of GRP75 in HepG2^PC and HepG2^B[a]P cells. D and F After transfection, flow cytometric analyses of the percentage of cells in apoptosis under the treatment of 10.0 μM cisplatin. E and G Transfected cells were treated with different concentrations of CDDP (0.0 to 100.0 μM) and sorafenib (0.0 to 100.0 μM) for 24 h, cell viability was determined in triplicate, and IC₅₀s were calculated.