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. 2023 Apr 11;14:2045. doi: 10.1038/s41467-023-37873-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a, b Cytokine and growth factor levels in the BAL and plasma were determined by multiplex analysis (n = 3 for saline group, n = 4 for OVA group). c A dot plot of comparison analysis of OVA-challenged versus saline-treated Mcemp1^+/+ mice in comparison with OVA-challenged versus saline-treated Mcemp1^–/– mice. The color bar indicates z-score of a predicted activation in the indicated pathway. The size of each dot corresponds to the p-value of overlap (right-tailed Fisher’s Exact Test). d Heatmaps of significantly upregulated and downregulated genes in OVA-challenged versus saline-treated Mcemp1^+/+ mice in comparison with OVA-challenged versus saline-treated Mcemp1^–/– mice. Red, white, and blue indicate induction, no change, and repression, respectively. e Gene expression of Il13, Il5, Il10, Ccl2, Ccr5, and Cxcl10 in Mcemp1^+/+ mice or Mcemp1^–/– mice after saline or OVA challenge. Data are presented as violin plots with lines at median and quartiles and p-values were determined by two-way ANOVA with Sidak’s multiple comparison in a, b, e. ns, not significant.