Fig. 3. TP53^mut was enriched in complex karyotype (CK) and is associated with significantly poor outcome of CK t-MN.

A Frequency of TP53^mut according to number of structural cytogenetic abnormalities; B High frequency of TP53^mut in typical-CK compared to atypical-CK t-MN; C TP53^mut cases were enriched for CK; D In the absence of CK, TP53^mut were prevalent in cases with 5q loss compared to 7q loss (+, present; -; absent; +/-, present or absent). Loss of 5q was defined as monosomy 5 or del 5q, while loss of 7q was defined as monosomy 7 or del 7q; E CK is associated with significantly poor survival in t-MN; F TP53^mut status further stratify CK with very poor outcome.