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. 2023 Apr 11;13(1):51. doi: 10.1038/s41408-023-00821-x

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Distribution of t-AML and t-MDS according to TP53^mut status; B TP53^mut frequency in t-MDS was similar across blast categories at diagnosis; C Chromosomal aberrancies and TP53^mut allelic status across BM blast %; D Multivariate Cox-regression analysis showing BM blast >10%, chromosomal 18/19 abnormalities and disease modifying therapies were independent predictors of TP53^mut OS; E In TP53^mut t-MN, BM blast 10–19% and ≥20% were associated with poor OS compared to BM blast <5%; (F) OS of TP53^mut t-MN according to ICC blast categories (0–9% vs. 10–19% vs. ≥20%).