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. 2023 Mar 29;14:1148255. doi: 10.3389/fmicb.2023.1148255

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Copyright © 2023 Facciuolo, Van Kessel, Kroeker, Liao, Lew, Falzarano, Kelvin, Gerdts and Napper.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Durability and kinetics of SARS-CoV-2-specific antibody responses. (A,B) Spike (S1)- and (C,D) RBD-specific IgG antibody titers after (A,C) primary infection and (B,D) reinfection. (A,C) Antigen-specific IgG titers were measured at 2, 4, 6, and 12 months post-primary infection and (B,D) 14 days after reinfection at each of the time intervals. Antigen-specific IgG titers were measured against spike S1 subunit and RBD antigens derived from ancestral Wuhan strain SARS-CoV-2, Delta, and Omicron. Each dot represents an individual hamster, the black horizontal bar represents the group median. P-values were calculated using a Kruskal-Wallis one-way ANOVA. *p < 0.05; **p < 0.01.