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. 2023 Mar 29;11:1089775. doi: 10.3389/fchem.2023.1089775

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Copyright © 2023 Chang, Wu, Lu, Du, Long, Zhu and Qin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The synthesis procedure of Pc-Fe and (B) schematic illustration of IBD relief with Pc-Fe. (B) During the process of acute inflammation (left part), the levels of ROS increased and harmful bacteria may attach to the injured intestinal epithelium, which inhibit commensal microbes to colonize and make function and destroy the gut barrier by up-regulating pro-inflammatory factors. After Pc-Fe intervention (right part), the levels of ROS decreased and probiotics Acidimicrobiia increased, which alleviated the progression of acute intestinal inflammation through down-regulating the pro-inflammatory factors, and expelling potential pathogenic bacteria.