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. 2023 Mar 29;11:1089775. doi: 10.3389/fchem.2023.1089775

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Copyright © 2023 Chang, Wu, Lu, Du, Long, Zhu and Qin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pc-Fe alleviates UC in the DSS-induced colitis model. (A) Body weight of mice in each group for 7 days. (B) The DAI score in each group. (C) Representative images of the colon in the PBS group, the DSS + PBS group, the DSS+5-ASA group and the DSS + Pc-Fe group on 7th day. (D) Colon length shown as a chart. (E) The HDI scores in each group based on inflammatory cell infiltration and mucosal damage under microscopic observation. TMB is colorless and transparent; TMB + H₂O₂ is dark blue; TMB + H₂O₂+Pc-Fe is pale blue. (F) Representative images of the anus in the PBS group, the DSS + PBS group, the DSS+5-ASA group and the DSS + Pc-Fe group on 7th day. . One-way ANOVA test was utilized, and data were shown as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.