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In vivo hF9 gene KI into the Serpinc1 locus restored coagulation activity
(A) Coagulation activity of different groups analyzed based on aPPT (n = 7–8 per group). (B) Thrombin-generation potential, analyzed using a calibrated automated thrombogram (n = 3 per group). Each dot represents data from an individual mouse. Data are presented as mean ± standard error of mean, calculated using one-way ANOVA. (∗∗∗p < 0.001, ∗∗∗∗p < 0.0001).
