TABLE 1.

Functional annotation for the selected 20 hub genes.

Biological function	Adjusted p-value	Involved genes
Ion channel complex	2.87E-25	CACNA1H, GABRA2, GABRA5, GABRB2, GABRP, GABRR1, GRIA1, GRIK2, KCNQ2, PKD2L1, SCN10A, TRPC1, TRPC7
TRPs channels	9.46E-8	TRPC1, TRPC7, TRPV4
Sodium channel activity	5.44E-10	CACNA1H, GRIK1, GRIK2, PKD2L1, SCN10A
Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	3.06E-12	GABRA2, GABRA5, GABRB2, GABRP, GABRR1, GRIA1, GRIK1, GRIK2, NGF