Table 2.
Summary current studies on MDSCs in tuberculosis patients.
| Samples | Source of MDSCs | Subtypes and phenotypic markers of MDSCs | Frequency of MDSCs | Cytokines | Reference |
|---|---|---|---|---|---|
| N=62(TB=43(low responders (LR-TB):23, high responders (HR-TB):20); HD=19) | PBMC | M-MDSCs: CD14+CD33+CD11b+CD15-HLA-DR-/low; PMN-MDSCs: CD15+CD33+CD11b+CD14-HLA-DR-/low | M-MDSCs and PMN-MDSCs ↑ (M-MDSCs ↑ in LR-TB; PMN-MDSCs ↑ in HR-TB) | IFN-γ↓ (in LR-TB) | (70) |
| N=48 (active TB=38; HD=10) | PBMC | M-MDSCs: Lin-HLA-DR-/lowCD33+CD11b+CD14+CD15-; PMN-MDSCs: Lin-HLA-DR-/lowCD33+CD11b+CD14-CD15+; e-MDSCs: Lin- (CD3/CD14/CD15/CD19/56)HLA-DR-CD33+ | M-MDSCs↑ (as compared to recovered and HDs) | IL-6 ↑ | (67) |
| N=45 (active TB=35; HD=10) | PBMC and bronchoalveolar cells (BALc) | PMN-MDSCs: CD11b+CD14-CD33+CD15+HLA-DRlow; M-MDSCs : CD11b+CD14+CD33+ HLA-DRlow; MDSCs: HLA-DR-/lowCD11b+CD33+ | MDSCs ↑ (in PBMCs and BALc); PMN-MDSCs ↑ (as compared to HDs) | None | (6) |
| N=230 (active TB=110; latent TB infection (LTBI)=80; HD=40) | PBMC | PMN-MDSCs: CD14-CD15+CD11b+CD33+HLA-DRlow/−; M-MDSCs: CD14+CD15-CD11b+CD33+HLA-DRlow/-; MDSCs: CD33+ HLA-DR-/LOW | MDSCs↑ (as compared to HDs) | IFN-γ↓ | (68) |
| active TB and household contacts (HHC) | PBMC and/or pleural fluid | MDSCs: LIN-/lo HLA-DR+CD33+CD11b+; M-MDSCs: HLA-DR-/loCD11b+CD14+ or S100A9+; PMN-MDSCs: HLA-DR-/loCD11b+CD15+ | MDSCs↑ | IL-1β, IL-6, IL-8, G-CSF,MCP-1↑; GM-CSF and MIP-1β↓ | (65) |
| N=16 (standard TB treatment=8; standard TB treatment+ COX-2i=8); | PBMC | NDSCs: HLA-DRneg/lowCD14+CD33+CD11b+ | M-MDSCs↑ | None | (69) |
| N=49 (active TB=19; latent TB infection (LTBI)=18; HD=12) | PBMC | PMN-MDSCs: HLA-DR-/lowCD11b+CD14-CD15+/CD66b+; M-MDSCs: HLA-DR-/lowCD11b+CD33+ CD14+CD15-; e-MDSCs: HLA-DR-CD33+CD15-Lin(CD3-CD56-CD19-CD14-) | PMN-MDSCs ↑ (as compared to LTBI and HDs) | None | (71) |
| N=33 (active TB=23; latent TB infection (LTBI)=10) | PBMC | e-MDSCs: LIN1-HLA-DR-/lowCD11b+CD33+; PMN-MDSCs: HLA-DR-/lowCD14-CD15+CD33+/dim; M-MDSCs: HLA-DR-/lowCD14+CD15-CD33+ | PMN-MDSCs↑ (as compared to LTBI) | None | (72) |
IFN-γ, interferon-γ; IL-1β, interleukin-1β; IL-6, interleukin-6; IL-8, interleukin-8; G-CSF, granulocyte-colony stimulating facto; GM-CSF, granulocyte-macrophage colony stimulating factor; MCP-1, monocyte chemotactic protein-1; MIP-1β, macrophage inflammatory protein 1β.
↑ represents increased and ↓ represents decreased.