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. 2023 Mar 29;14:1117310. doi: 10.3389/fimmu.2023.1117310

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Copyright © 2023 Cai, Wu, Lai, Yao, Zeng, Fang, Lin, Chen, Xu and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LDC7559 Treatment Inhibited GSDMD-mediated Signaling after SAH. Representative western blot bands (A) and quantification of the protein levels of NLRP3 (B), caspase-1 (C), cleaved caspase-1 (D), GSDMD (E), and cleaved GSDMD (F) (n = 6 per group). Representative immunofluorescence microphotographs of NLRP3 staining (G) in the ipsilateral hemisphere. Scale bar = 50 μm. Measurement of NLRP3 staining in the ipsilateral hemisphere (H) (n = 6 per group). Values are presented as the mean ± SD. ^@ P < 0.05 compared with sham group, *P < 0.05 compared with SAH + vehicle group, ^& P < 0.05 compared with SAH + 20mg/kg LDC7559 group.