Table 2.
Certainty of evidence for each outcome estimated in this systematic review and meta‐analysis using the GRADE approach.
| Outcome | Number of participants (number of studies) included for each analysis | Effect size (95% confidence interval) | Quality of evidence | Overall certainty |
|---|---|---|---|---|
| Nitric oxide metabolites' concentration | 196 (6) | 1.50 (0.48–1.82) |
⊕⊖⊖⊖ Due to risk of bias, indirectness of the evidence and imprecision |
Very low |
| Hemoglobin (g/dl) | 138 (5) | 0.49 (−0.43 to 1.41) |
⊕⊕⊖⊖ Due to risk of bias and imprecision |
Low |
| Fetal hemoglobin (%) | 56 (3) | 1.69 (0.86–2.52) |
⊕⊕⊖⊖ Due to risk of bias and imprecision |
Low |
| Reticulocyte | 88 (3) | −0.40 (−1.40 to 2.20) |
⊕⊖⊖⊖ Due to risk of bias, imprecision and inconsistency |
Very low |
| Malondialdehyde | 102 (4) | −0.95 (−2.21 to 0.32) |
⊕⊖⊖⊖ Due to risk of bias, imprecision and inconsistency |
Very low |
| Systolic blood pressure (mmHg) | 142 (3) | −8.46 (−15.58 to −1.33) |
⊕⊕⊖⊖ Due to risk of bias and imprecision |
Low |
| Diastolic blood pressure (mmHg) | 142 (3) | −3.40 (−18.52 to 11.71) |
⊕⊖⊖⊖ Due to risk of bias, imprecision and inconsistency |
Very low |
| Alanine transaminase | 96 (3) | −0.74 (−1.98 to 0.50) |
⊕⊕⊖⊖ Due to risk of bias and imprecision |
Low |
| Aspartate transaminase | 96 (3) | −0.49 (−0.73 to −0.26) |
⊕⊕⊖⊖ Due to risk of bias and imprecision |
Low |