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. 2023 Feb 6;46(4):794–800. doi: 10.2337/dc22-1833

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© 2023 by the American Diabetes Association

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/journals/pages/license.

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Improvement of eMERGE type 1 diabetes algorithm with inclusion of polygenic scores. The PPV of specified type 1 diabetes algorithms is shown for individuals in the MGB Biobank or BioMe, as classified by self-reported race (White vs. non-White). Values are displayed for the original eMERGE type 1 diabetes algorithm, as well as for modified versions that also require individuals to have a polygenic score greater than a specified cutoff value (T1D-rsPS_EUR (13) or T1D-rsPS_AFR (14)). The optimal cutoff value was identified in a separate cohort (UK Biobank). The raw number of individuals with verified and misclassified type 1 diabetes is displayed beneath the graph. Statistical significance was assessed with two-sample test of proportions. *P < 0.05, **P < 0.005.