Figure 2.

A–D: Cumulative hazard of the primary composite outcome, kidney-specific composite outcome, ESKD, or cardiorenal death in participants with H-mGFR or L-mGFR compared with those with N-mGFR. The primary outcome was a composite of a doubling of serum creatinine levels from baseline, incident ESKD (defined as the initiation of dialysis, kidney transplantation, or an eGFR <15 mL/min/1.73 m²), or death from cardiovascular or renal causes. The kidney-specific outcome was a composite of a doubling of serum creatinine level, ESKD, or death from renal cause. Cox proportional hazards regression models adjusted for age, sex, BMI, diabetes type and duration, HbA_1c, systolic blood pressure, and log-transformed albuminuria were used to calculate HRs 95% CIs for the H-mGFR and L-mGFR groups vs. the N-mGFR group.