Table 2.
Primary and secondary outcomes
| H-mGFR (n = 63) | N-mGFR (n = 188) | L-mGFR (n = 63) | H-mGFR vs. N-mGFR | L-mGFR vs. N-mGFR | H-mGFR vs. L-mGFR | ||||
|---|---|---|---|---|---|---|---|---|---|
| Outcome | n (%)/event ratea | n (%)/event ratea | n (%)/event ratea | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P |
| Primary composite outcome | 25 (39.7)/23.9 | 46 (24.5)/13.5 | 24 (38.1)/24.3 | 2.09 (1.25–3.49) | 0.005 | 1.81 (1.05–3.16) | 0.033 | 1.15 (0.62–2.15) | 0.653 |
| Kidney-specific composite outcome | 14 (22.2)/13.4 | 14 (7.5)/4.1 | 16 (25.4)/16.2 | 4.95 (2.21–11.09) | <0.0001 | 3.81 (1.70–8.56) | 0.001 | 1.30 (0.54–3.11) | 0.555 |
| Doubling of serum creatinine level | 14 (22.2)/13.6 | 14 (7.5)/4.2 | 16 (25.4)/16.9 | 4.86 (2.18–10.90) | 0.0001 | 4.04 (1.77–9.20) | 0.0009 | 1.20 (0.50–2.89) | 0.678 |
| ESKD | 3 (4.8)/2.7 | 2 (1.1) /0.6 | 15 (23.8)/14.7 | 4.39 (0.59–32.50) | 0.147 | 23.61 (4.87–114.86) | <0.0001 | 0.19 (0.04–0.91) | 0.038 |
| eGFR <15 mL/min/1.73 m2 | 2 (3.2)/1.9 | 1 (0.5)/0.3 | 13 (20.6)/13.7 | 4.97 (0.30–82.98) | 0.265 | 46.51 (5.57–388.30) | 0.0004 | 0.11 (0.01–0.92) | 0.042 |
| Dialysis initiated or kidney transplantation | 2 (3.2)/1.8 | 2 (1.1)/0.6 | 12 (19.1)/10.5 | 4.91 (0.61–39.58) | 0.135 | 17.31 (3.18–94.07) | 0.001 | 0.28 (0.05–1.48) | 0.135 |
| Cardiorenal death | 20 (31.8)/18.1 | 41 (21.8)/11.9 | 23 (36.5)/21.4 | 2.18 (1.24–3.83) | 0.007 | 2.26 (1.27–4.01) | 0.006 | 0.97 (0.50–1.89) | 0.920 |
| Renal death | 1 (1.6)/0.9 | 0 (0)/0 | 3 (4.8)/2.8 | NA | NA | NA | NA | 0.39 (0.02–8.17) | 0.542 |
| Cardiovascular death | 19 (30.2)/17.2 | 41 (21.8)/11.9 | 20 (31.8)/18.6 | 2.05 (1.16–3.63) | 0.014 | 1.98 (1.09–3.60) | 0.026 | 1.04 (0.52–2.08) | 0.921 |
| Death from any cause | 26 (41.3)/23.5 | 66 (35.1)/19.1 | 29 (46.0)/27.0 | 1.62 (1.00–2.61) | 0.049 | 1.65 (1.02–2.68) | 0.041 | 0.98 (0.54–1.75) | 0.938 |
The primary outcome was a composite of a doubling of serum creatinine levels from baseline, incident ESKD (defined as the initiation of dialysis, kidney transplantation, or an eGFR <15 mL/min/1.73 m2), or death from cardiovascular or renal causes. The kidney-specific outcome was a composite of a doubling of serum creatinine level, ESKD, or death from renal cause. Cox proportional hazards models adjusted for age, sex, BMI, diabetes type and duration, HbA1c, systolic blood pressure, and log-transformed albuminuria were used to estimate HRs and 95% CIs for the primary and secondary outcomes according to the mGFR-based grouping at baseline. NA, not applicable.
a
Number of events per 1,000 person-years.