Characteristics of primers used in the study

Gene	Sequence
NOTCH4	Forward: 5′-ACA CAG GCT CCC GTT GTG AG-3′
	Reverse: 5′-GGC ACA CTC GTT GGT CTC CA-3′
NRP2	Forward: 5′-CTC GGC TTT TGC AGG TGA GAA T-3′
	Reverse: 5′-TGC TCC AGT CCA CCT CGT AT-3′
PLAT	Forward: 5′-TGG AGC AGT CTT CGT TTC GC-3′
	Reverse: 5′-CCA TGA CTG ATG TTG CTG GTA-3′
PLAU	Forward: 5′-CCT GGG TCG CTC AAG GCT TA-3′
	Reverse: 5′-CAC ACC TGC CCT CCT TGG AA-3′
NOTCH1	Forward: 5′-GCT CAC GCT GAC GGA GTA CA-3′
	Reverse: 5′-ATG GAA GCT GGG TGG GCA GT-3′
FLT1	Forward: 5′-ACG GCC AGC GAG TAC AAA G-3′
	Reverse: 5′-AGT CAC GTT TGC TCT TGA GG-3′
COL4A2	Forward: 5′-CAG GTT TTC CGG GAC TCC GT-3′
	Reverse: 5′-AAG GGT GTT GGC CTC TCC TG-3′
CD34	Forward: 5′-GTC TTC CAC TCG GTG CGT CT-3′
	Reverse: 5′-TGG GGT AGC AGT ACC GTT GT-3′
SERPINE1	Forward: 5′-CGC CGC CTC TTC CAC AAA TC-3′
	Reverse: 5′-AGG GCA GTT CCA GGA TGT CG-3′
HEY2	Forward: 5′-ACC TCC GAG AGC GAC ATG GA-3′
	Reverse: 5′-CGA TCC CGA CGC CTT TTC TC-3′
MKI67	Forward: 5′-GAC TTG ACG AGC GGT GGT TC-3
	Reverse: 5′-GGG AAG GCC AGG TAT AAT CCG T-3′
KLF4	Forward: 5′-GAA AAG GAC CGC CAC CCA CA-3′
	Reverse: 5′-AGC GGG CGA ATT TCC ATC CA-3′
LYVE1	Forward: 5′-TGA AGG GGT AGG CAC GAT GG-3′
	Reverse: 5′-GCA TGA CAC CTG GAT GGA AAG C-3′
FLT4	Forward: 5′-TGT GGT CCT TTG GGG TGC TT-3′
	Reverse: 5′-CCC TCA TCC TTG TGC CGT CT-3′