Table 2.

Immunoadsorption treatment plan

Patient number	Baseline titer		IA sessions planned	IA sessions performed	Mean PV treated per IA session	Titer at transplantation
	IgG	IgM				IgG	IgM
1	128	32	6	6	2.5	2	2
2	32	32	5	5	2.2**	neg	4
3	32	32	5	5	2.5	4	4
4	16	16	5	5	2.5	neg	2
5	32	32	5	5	2.5	neg	2
6	256	16	7	5	2.5	2	1
7	32	8	5	5	2.4	neg	1
8*	16	2	4	6	3.3	2	1
9	4	16	4	4	3	neg	4
10*	256	16	6	10	3.4	8	1
11	256	32	6	6	3.3	4	neg
12*	128	16	6	3***	4	4	1
13	64	16	6	4****	2.5	4	neg

Isohemagglutinin titers for IgG and IgM at baseline were considered to plan the number of IA sessions based on the estimation that one IA session was able to lower isohemagglutinins by one titer level. For logistical reasons, a margin was used at the discretion of the treating nephrologist. Generally, 2.5 patient's plasma volumes (PV) were processed per IA session. This was increased up to 4 plasma volumes per session if the titer reduction was insufficient. IA, immunoadsorption; PV, plasma volumes (calculated with the formula of Nadler).

^*In 3 patients, in response to insufficient titer lowering the processed PV per IA session was increased and the transplant postponed.

^**Last IA was interrupted because of clumping in the filter.

^***Because of low blood pressure during IA and hemodialysis, anticoagulation was switched from ACD-A to heparin after 7 IA sessions to facilitate higher flow rates. Sessions with citrate anticoagulation are not included in the analysis.

^****Two plasma exchange sessions (not included in the analysis) were performed before switching to IA heparin for logistical reasons as the Glycosorb column was not available on time.