Table 1.
Demographic and clinical information from included cohorts
| Discovery (n = 3398) | Replication (n = 3445) | |||
|---|---|---|---|---|
| WiSC, n = 962 | MrOS, n = 2436 | HypnoLaus, n = 1388 | MESA, n = 2057 | |
| Age (year) | 55.9 ± 7.7 | 76.5 ± 5.6 | 52.6 ± 10.5 | 69.6 ± 9.2 |
| Sex, male (n (%)) | 512 (53%) | 2436 (100%) | 776 (48.4%) | 1036 (46%) |
| Ethnicity | European | European | European | (573 African, 743 European, 250 East Asian, 491 Native American) |
| BMI (kg/m2) | 31.6 ± 7.2 | 27.2 ± 3.8 | 26.0 ± 4.3 | 28.8 ± 5.3 |
| PLMI (PLMS/h) | 6.4 [2.0, 16.9] | 24.3 [3.4, 56.5] | 2.4 [0.0, 19.8] | 2.6 [0.0, 18.3] |
| PLMS+ (n (%)) | 275 (29%) | 1470 (60%) | 425 (31%) | 577 (26%) |
| Platform | Affymetrix 6.0/500k | Illumina | Affymetrix | Illumina |
| Study type | Population based | Population based | Clinical sample | Population based |
| PLMS ascertainment | EMG; validated PLM detector algorithm [2, 25] | Piezoelectric; manual annotation | EMG; WASM criteria | Piezoelectric; manual annotation |
Note: BMI, body mass index; EMG, electromyography; PLMI, periodic limb movement index; PLMS, periodic limb movements in sleep; PLMS+PLMI ≥ 15 events per hour; WASM, World Association of Sleep Medicine. Values for age and BMI are presented as mean ± standard deviation. Values for PLMI are presented as a mean with a 95% confidence interval.