Table 4.
Meta-analysis of PLMI SNPs compared with the loci associated with insomnia (Posthuma et al. 2020)
| Marker information | PLMI (this study) | Insomnia (Posthuma et al. 2020) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Marker name | Band | MAF | ref | alt | Gene | Top SNP | Beta | SE | P-value | #SNPs in LD | Beta | SE | P-value |
| rs9394502 | 6p21.2 | 0.3918 | T | C | BTBD9 | 1 | −0.1587 | 0.0202 | 3.92E−15 | 23 | -0.009 | 0.001 | 3.53E-20 |
| rs62144053 | 2p14 | 0.0901 | A | G | MEIS1 | 1 | 0.3626 | 0.0528 | 6.81E−12 | 4 | 0.025 | 0.002 | 2.56E−53 |
| rs72826719 | 2p14 | 0.0512 | A | G | MEIS1 | 0 | 0.3422 | 0.0735 | 3.19E−06 | 2 | 0.022 | 0.002 | 3.85E−23 |
| rs11126082 | 2p14 | 0.4722 | C | G | MEIS1 | 0 | −0.107 | 0.0278 | 0.0001179 | 2 | −0.009 | 0.001 | 3.36E−20 |
| rs77614227 | 15q14 | 0.9486 | G | T | AC021351.1 | 0 | −0.1793 | 0.0517 | 0.0005218 | 2 | −0.012 | 0.002 | 4.74E−09 |
| rs4238749 | 16q12.2 | 0.4459 | A | C | CASC16 | 0 | −0.0624 | 0.0193 | 0.001253 | 103 | −0.007 | 0.001 | 9.34E−16 |
| rs11980428 | 7q21.13 | 0.2607 | A | G | AC002127.2 | 1 | 0.0798 | 0.0249 | 0.001325 | 84 | 0.009 | 0.001 | 1.06E−11 |
| rs68030046 | 6p21.2 | 0.0606 | A | G | BTBD9 | 0 | −0.137 | 0.0433 | 0.001548 | 2 | −0.01 | 0.002 | 1.06E−08 |
| rs8025163 | 15q23 | 0.1117 | T | C | IQCH | 1 | −0.0988 | 0.032 | 0.002026 | 2 | −0.008 | 0.001 | 1.32E−08 |
| rs118166957 | 9p24.1 | 0.1667 | T | C | PTPRD | 1 | 0.0834 | 0.0272 | 0.002133 | 25 | 0.012 | 0.001 | 2.46E−20 |
Note: MAF, minor allele frequency; ref, reference allele; alt, alternative allele; TopSNP is the most significant (smallest P-value) SNP within LD block, binarized as yes (1) or no (0); #SNPs in LD number of significant SNPs in linkage disequilibrium with SNP; SE, standard error.