Table 5.

Genome-wide correlations with PLMI, RLS, insomnia, iron deficiency anemia, and stroke

Phenotype 1	Phenotype 2	R g	se	z	P	h2_obs	h2_obs_se	N (p2 cases)
PLMI	Restless legs syndrome	0.4229	0.20	2.15	0.0317	0.4175	0.0586	6228
PLMI	Sleeplessness/insomnia	0.2645	0.11	2.36	0.0182	0.0642	0.0027	360,738
PLMI	Iron-deficiency anemia	0.0038	0.30	0.01	0.9900	0.0046	0.0013	2557
PLMI	Stroke*	0.9308	0.42	2.24	0.0250	0.0041	0.0013	8178
Restless legs syndrome	Stroke*	0	0.14	0.21	0.8350	0.0037	0.0013	8178
Restless legs syndrome	Sleeplessness/insomnia	0.2752	0.05	5.31	1.13E-07	0.0654	0.003	360,738
Restless leg syndrome	Iron-deficiency anemia	0.2619	0.13	2.00	0.0450	0.0045	0.0015	2557
Stroke*	Sleeplessness/insomnia	0.3755	0.09	4.11	3.88E-05	0.0638	0.0028	360,738
Stroke*	Iron-deficiency anemia	0.4113	0.24	1.73	0.0829	0.0048	0.0013	2557
Iron-deficiency anemia	Sleeplessness/Insomnia	0.2358	0.08	3.12	0.0018	0.0638	0.0028	360,738

*Vascular/heart problems diagnosed by doctor: stroke.

Note: R _g , correlation between phenotypes (Pairwise); se, standard error; h2_obs, observed heritability of phenotype pair (on the liability scale); h2_obs_se, standard error of the observed heritability; N (p2 cases), sample size of the cases in the phenotype 2 study.