Table 6.

MR methods testing the causal relationship between RLS as an exposure and PLMS+ as an outcome

Method	Estimate	Std error	95% CI upper	95% CI lower	P-value
Simple median	0.559	0.049	0.464	0.654	<0.001
Weighted median	0.694	0.048	0.601	0.788	<0.001
Penalized weighted median	0.710	0.048	0.616	0.803	<0.001
IVW	0.558	0.033	0.494	0.623	<0.001
Penalized IVW	0.575	0.031	0.513	0.636	<0.001
Robust IVW	0.570	0.035	0.501	0.639	<0.001
Penalized robust IVW	0.577	0.033	0.513	0.641	<0.001
MR-Egger	0.732	0.085	0.565	0.899	<0.001
(intercept)	−0.028	0.013	−0.054	−0.003	0.027
Penalized MR-Egger	0.755	0.081	0.596	0.914	<0.001
++(intercept)	−0.029	0.012	−0.053	−0.005	0.018
Robust MR-Egger	0.769	0.102	0.570	0.969	<0.001
(intercept)	−0.032	0.016	−0.063	−0.002	0.037
Penalized robust MR-Egger	0.777	0.099	0.583	0.970	<0.001
(intercept)	−0.032	0.015	−0.062	−0.003	0.033

Notes: IVW—inverse-variance weighted, MR-Egger—Mendelian randomization Egger method.