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. 2023 Apr 11;329(14):1170–1182. doi: 10.1001/jama.2023.3546

Figure 2. Primary Outcome of Oxygen-Free Days Between Randomization and Day 28 in the TXA-127 Trial and in the TRV-027 Trial.

Figure 2.

The day of randomization was study day 0. The total sample size was 343 patients in the TXA-127 trial. The total sample size was 290 patients in the TRV-027 trial. Patients were followed up until the earlier of death or day 28. The numbers at risk shown in panels A and B are the numbers of patients who were not deceased, withdrawn, or lost to follow-up. The plots in panels C and D display the proportion of patients in each of the 30 levels (range, −1 to 28 days) of the oxygen-free days ordinal scale at day 28. The oxygen-free days outcome demonstrated null results for TXA-127 vs placebo and TRV-027 vs placebo with point estimates in the direction of inferiority for the TXA-127 trial (adjusted OR, 0.88 [95% credible interval, 0.59 to 1.30]) and for the TRV-027 trial (adjusted OR, 0.74 [95% credible interval, 0.48 to 1.13]).