Table 3.
Association of major depressive disorder with sociodemographic, clinical, and surgical variables in the included patients with Crohn's disease.
| Variable | MDD |
OR | CI (95%) |
p | ||
|---|---|---|---|---|---|---|
| None/mild | Moderate/severe | Lower | Upper | |||
| Gender | <0.001 | |||||
| Female | 80 (48.2) | 86 (51.8) | 1.00 | <0.001 | ||
| Male | 85 (72.6) | 32 (27.4) | 0.35 | 0.21 | 0.58 | |
| Age at diagnosis (year) | 1.001 | 0.982 | 1.019 | 0.952a | ||
| Mean ± SD | 32.5 ± 12.9 | 32.6 ± 13 | ||||
| Median (mín.; máx.) | 31 (10; 71) | 31.5 (10; 66) | ||||
| Age at onset | 0.747 | |||||
| 16 years or younger | 10 (50) | 11 (50) | 1.00 | |||
| 17 to 40 years | 113 (58.9) | 79 (41.1) | 0.70 | 0.28 | 1.76 | |
| 40 years | 40 (58) | 30 (42) | 0.73 | 0.26 | 1.97 | |
| Hemoglobin (g/dL) | 0.860 | 0.740 | 1.000 | 0.071a | ||
| Mean ± SD | 13.2 ± 1.7 | 12.9 ± 1.8 | ||||
| Median (mín.; máx.) | 13.3 (7.6; 16.7) | 12.8 (8.8; 16.8) | ||||
| Hematocrit (%) | 0.930 | 0.880 | 0.980 | 0.006a | ||
| Mean ± SD | 39.8 ± 4.5 | 38.3 ± 4.5 | ||||
| Median (mín.; máx.) | 40.1 (21.7; 49.3) | 38 (27.5; 48.4) | ||||
| C- reactive protein (mg/dL) | 1.010 | 1.000 | 1.020 | 0.206b | ||
| Mean ± SD | 10 ± 17.3 | 15.3 ± 31.6 | ||||
| Median (mín.; máx.) | 3 (0.1; 97.2) | 4.6 (0.3; 257) | ||||
| Surgeries | 0.212 | |||||
| Yes | 110(59.1) | 76 (40.9) | 1.00 | |||
| No | 55 (56.7) | 42 (43.3) | 1.32 | 0.77 | 2.24 | |
| Disease duration (years) | 0.968 | 0.942 | 0.995 | 0.021a | ||
| Mean ± SD | 14.3 ± 8.9 | 11,8 ± 8.6 | ||||
| Median (mín.; máx.) | 14 (1; 38) | 11 (1; 40) | ||||
| Remission | <0.001 | |||||
| Yes | 146 (94.2) | 9 (5.8) | 1.00 | |||
| No | 19 (14.8) | 109 (85.2) | 93.06 | 40.54 | 213.64 | |
| 5-Aminosalicylic acid | 0.731 | |||||
| Yes | 61 (57) | 46 (43) | 1.09 | 0.67 | 1.77 | |
| No | 104 (59.1) | 72 (40.9) | 1.00 | |||
| Immunosuppressant | 0.709 | |||||
| Yes | 89 (59.3) | 61 (40.7) | 0.91 | 0.57 | 1.47 | |
| No | 76 (57.1) | 57 (42.9) | 1.00 | |||
| Anti-TNF biological | 0.123 | |||||
| Yes | 70 (53.4) | 61 (46.6) | 1.45 | 0.90 | 2.34 | |
| No | 95 (62.5) | 57 (37.5) | 1.00 | |||
| Corticosteroid use | >0.999* | |||||
| Yes | 2 (50) | 2 (50) | 1.41 | 0.20 | 10.12 | |
| No | 163 (58.4) | 116 (41.6) | 1.00 | |||
MDD, Major Depressive Disorder; OR, Odds Ratio; CI, Confidence Interval; TNF, Tumoral Necrosis Factor; SD, Standard Deviation.
a
Student t-test.
b
Mann-Whitney test.
Chi-Squared Test; # Likelihood radio test.