Table 1.
Baseline characteristics of ILI and SC cohorts of patients with type 1 diabetes and obesity
|
ILI (n = 77) |
SC (n = 77) |
p value† | |
|---|---|---|---|
| Age (years) | 43 ± 12 | 43 ± 12 | NS |
| Female n (%) | 50 (65) | 50 (65) | NS |
| Diabetes duration (years) | 22 ± 12 | 22 ± 9 | NS |
| Weight (kg) | 102.5 ± 17.3 | 100.9 ± 17.2 | NS |
| BMI (kg/m2) | 35.7 ± 5.0 | 35.3 ± 4.9 | NS |
| ALT (U/L) | 26.8 ± 20.2 | 21.6 ± 8.5 | < 0.05 |
| AST (U/L) | 22.4 ± 9.3 | 21.7 ± 12.0 | NS |
| HbA1c (%) | 8.2 ± 1.0 | 8.2 ± 0.9 | NS |
| HSI | 46.2 ± 6.1 | 44.9 ± 5.7 | NS |
| HSI > 36 n (%) | 77 (100) | 75 (97.4) | NS |
| HSI < 30 n (%) | 0 (0) | 0 (0) | - |
| Total insulin dose (units/d) | 69.9 ± 27.5 | 70.8 ± 27.4 | NS |
| Weight-adjusted insulin dose (units/kg/d) | 0.7 ± 0.2 | 0.7 ± 0.2 | NS |
| Use of insulin pump therapy n (%) | 49 (63.6) | 36 (46.7) | < 0.05 |
| Systolic blood pressure (mmHg) | 128 ± 14 | 126 ± 15 | NS |
| Diastolic blood pressure (mmHg) | 77 ± 8 | 77 ± 9 | NS |
| Total Cholesterol (mg/dL) | 169 ± 33 | 176 ± 26 | NS |
| LDL-Cholesterol (mg/dL) | 97 ± 32 | 97 ± 27 | NS |
| HDL-Cholesterol (mg/dL) | 55 ± 16 | 58 ± 17 | NS |
| Triglycerides (mg/dL) | 114 ± 88 | 121 ± 73 | NS |
Data are mean ± SD
ILI Intensive lifestyle intervention, SC Standard diabetes care, HSI Hepatic steatosis index, NAFLD Nonalcoholic fatty liver disease, ALT Alanine aminotransferase, AST Aspartate aminotransferase
†Student’s t-test or Pearson’s chi squared between groups