Figure 3.

Schematic representation of the PopPK/PD model. BLA, baseline value for the endogenous agonist (GnRH); BLR, baseline value for the GnRH receptor; BLT, baseline value for testosterone; Cp, relugolix plasma concentration; DR, receptor downregulation; DR₅₀, level of receptor activation at which receptor downregulation is at 50% of maximum; FRAC, fraction of activated GnRH receptors (by agonist); FRAC2, fraction of activated GnRH receptors (by agonist and antagonist); GnRH, gonadotropin‐releasing hormone (endogenous agonist); HILFD, Hill coefficient of the testosterone‐feedback on GnRH production; KD, receptor equilibrium dissociation constant; KinA, endogenous GnRH production rate constant; KinR, GnRH receptor production rate constant; KinT, testosterone production rate constant; KouR, GnRH receptor degradation rate constant; KouT, testosterone degradation rate constant; KoutA, endogenous GnRH degradation rate constant; nH, Hill coefficient of the downregulation of GnRH receptor production; PD, pharmacodynamic; PopPK, population pharmacokinetic; RAC, amount of activated receptors; Recpt, receptor; Testos, testosterone.