Figure 5.

Simulation of testosterone profile after treatment discontinuation. The shaded area represents the 90% prediction interval (5th to 95th percentile) of the simulations. The solid line represents the median of the simulations. Testosterone concentrations of ≥ 280 ng/dL, < 50 ng/dL, and < 20 ng/dL represent the normal range, castration levels, and profound castration levels, respectively. Relugolix was simulated to be administered for 40 days with 100% adherence followed by treatment discontinuation.