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. 2022 Oct 26;93(1):164–174. doi: 10.1002/ana.26516

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© 2022 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Schema shows the analysis process and data from two representative participants. (A) Analysis process from initial diffusion‐weighted imaging (DWI) images to calculate analysis along the perivascular space (ALPS) indexes and evaluate the associations with standardized uptake value ratios of amyloid (¹⁸F‐AV‐45) position emission tomography (PET) images and tau (¹⁸F‐APN 1607) PET images. (B) Images and data from 2 representative participants show the ¹⁸F‐AV‐45 PET images, ¹⁸F‐APN 1607 PET images, diffusion tensor imaging (DTI) images, and ALPS‐indexes. AD = Alzheimer disease; ICBM = International Consortium of Brain Mapping; MMSE = Mini‐Mental State Examination; MNI = Montreal Neurological Institute; NC = normal control; y/o = years old.