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. 2022 Oct 26;93(1):164–174. doi: 10.1002/ana.26516

FIGURE 3.

FIGURE 3

The schema of mediation analysis in the precuneus region and the topographical distribution of diffusion tensor image analysis along the perivascular space (ALPS) indexes as significant mediators after correction for age, sex, years of education and APOE4 genotype. (A). ALPS‐indexes are statistically significant mediators of the relationship between amyloid position emission tomography (PET), tau PET, and cognitive dysfunction in the precuneus. (B, C) The ALPS‐index significantly mediates the relationship between amyloid (A) and tau (B) deposition and cognitive dysfunction. A = anterior; P = posterior; R = right; S = superior. (D) The percent of mediation (Pm) analysis of ALPS‐indexes between regional amyloid and tau deposition and cognition from the indirect mediation analysis. (E) The Pm of ALPS‐indexes between regional amyloid and tau and gray matter volume (GMV) ratios. The significant regions are plotted on the different color bars. Nonsignificant (ns) regions are in white. Background regions are in gray. ACC = anterior cingulate cortex; CERAD‐NAB = Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Assessment Battery; F = frontal; O = occipital; P = parietal; PCC = posterior cingulate cortex; pHP = parahippocampus; PreCu = precuneus; S‐M = sensory–motor cortex; T = temporal.