Skip to main content
. 2022 Oct 26;93(1):164–174. doi: 10.1002/ana.26516

FIGURE 4.

FIGURE 4

Topographical distribution of diffusion tensor image analysis along the perivascular space (ALPS) indexes as significant mediators after correction for age, sex, years of education, APOE4 genotype, and regional gray matter volume (GMV) ratios. (A, B) The ALPS‐index significantly mediates the relationship between amyloid (A) and tau (B) deposition and cognitive dysfunction after correction for multiple covariates. A = anterior; P = posterior; R = right; S = superior. (C) The percent of mediation (Pm) of ALPS‐indexes between regional amyloid (A) and tau (T) deposition and cognition from the indirect mediation analysis. The significant regions are plotted on the different color bars. Nonsignificant (ns) regions are in white. Background regions are in gray. ACC = anterior cingulate cortex; CERAD‐NAB = Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Assessment Battery; F = frontal; O = occipital; P = parietal; PCC = posterior cingulate cortex; pHP = parahippocampus; PreCu = precuneus; S‐M = sensory–motor cortex; T = temporal.