TABLE 1.
Demographic Data of Patients with AD and NCs
| Characteristic | NCs (n = 13) | AD (n = 37) | p |
|---|---|---|---|
| Mean age, yr | 61.0 ± 7.1 | 63.2 ± 4.7 | 0.31 |
| Sex, male:female | 4:9 | 10:27 | 0.79 |
| Education, yr | 10.5 ± 3.5 | 10.9 ± 3.5 | 0.70 |
| Onset to scan time, yr | — | 3.9 ± 1.8 | |
| Mean MMSE score | 28.0 ± 1.2 | 17.7 ± 6.7 | <0.01 |
| Mean CERAD‐NAB total score | 81.2 ± 9.6 | 47.4 ± 18.3 | <0.01 |
| Mean CDR‐SB score | 0.0 ± 0.0 | 0.9 ± 0.4 | <0.01 |
| APOE4 genotype (positive:negative) | 2:11 | 13:24 | 0.18 |
| Mean cortical SUVRs of 18F‐AV‐45 | 1.1 ± 0.1 | 1.7 ± 0.3 | <0.01 |
| Mean cortical SUVRs of 18F‐APN1607 | 0.9 ± 0.1 | 1.8 ± 0.4 | <0.01 |
| Mean total GMV ratio, % | 41.4 ± 2.8 | 36.2 ± 3.3 | <0.01 |
| Mean total ICV, ml | 1,345.6 ± 143.4 | 1,353.7 ± 128.9 | 0.83 |
| Mean ALPS indexes | 1.5 ± 0.1 | 1.4 ± 0.2 | 0.04 |
AD = Alzheimer disease; ALPS = diffusion tensor image analysis along the perivascular space; APOE = apolipoprotein E; CDR‐SB = Clinical Dementia Rating sum of boxes; CERAD‐NAB = Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Assessment Battery; GMV = gray matter volume; ICV = intracranial volume; MMSE = Mini‐Mental State Examination; NC = normal control; SUVR = standardized uptake value ratio.