Comparison 2. Failure to respond (at 1 ‐ 4 weeks).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Paroxetine versus older ADs	4	526	Odds Ratio (M‐H, Fixed, 95% CI)	0.90 [0.61, 1.33]
1.1 versus amitriptyline	1	153	Odds Ratio (M‐H, Fixed, 95% CI)	1.06 [0.52, 2.15]
1.2 versus clomipramine	1	92	Odds Ratio (M‐H, Fixed, 95% CI)	0.58 [0.25, 1.37]
1.3 versus imipramine	1	159	Odds Ratio (M‐H, Fixed, 95% CI)	1.43 [0.61, 3.33]
1.4 versus lofepramine	1	122	Odds Ratio (M‐H, Fixed, 95% CI)	0.74 [0.35, 1.55]
2 Paroxetine versus SSRIs	3		Odds Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 versus fluvoxamine	3	281	Odds Ratio (M‐H, Fixed, 95% CI)	0.71 [0.41, 1.24]
3 Paroxetine versus newer or non‐conventional ADs	7		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 versus mirtazapine	3	726	Odds Ratio (M‐H, Random, 95% CI)	2.39 [1.42, 4.02]
3.2 versus reboxetine	3	1375	Odds Ratio (M‐H, Random, 95% CI)	0.66 [0.50, 0.87]
3.3 versus trazodone	1	108	Odds Ratio (M‐H, Random, 95% CI)	0.54 [0.25, 1.19]