Comparison 4. Failure to remit at endpoint (6 ‐ 12 weeks).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Paroxetine versus older ADs	3	401	Odds Ratio (M‐H, Random, 95% CI)	1.23 [0.49, 3.07]
1.1 versus clomipramine	1	120	Odds Ratio (M‐H, Random, 95% CI)	3.39 [1.50, 7.65]
1.2 versus imipramine	1	159	Odds Ratio (M‐H, Random, 95% CI)	0.75 [0.39, 1.43]
1.3 versus lofepramine	1	122	Odds Ratio (M‐H, Random, 95% CI)	0.80 [0.38, 1.66]
2 Paroxetine versus other SSRIs	7		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 versus escitalopram	2	784	Odds Ratio (M‐H, Random, 95% CI)	1.15 [0.60, 2.22]
2.2 versus fluvoxamine	3	261	Odds Ratio (M‐H, Random, 95% CI)	0.78 [0.44, 1.38]
2.3 versus sertraline	2	545	Odds Ratio (M‐H, Random, 95% CI)	0.94 [0.67, 1.34]
3 Paroxetine versus newer or non‐conventional ADs	20		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 versus agomelatine	1	284	Odds Ratio (M‐H, Random, 95% CI)	1.27 [0.75, 2.14]
3.2 versus amisulpride	1	277	Odds Ratio (M‐H, Random, 95% CI)	0.85 [0.49, 1.46]
3.3 versus duloxetine	6	1821	Odds Ratio (M‐H, Random, 95% CI)	0.98 [0.80, 1.19]
3.4 versus hypericum	1	251	Odds Ratio (M‐H, Random, 95% CI)	1.84 [1.11, 3.06]
3.5 versus milnacipran	1	302	Odds Ratio (M‐H, Random, 95% CI)	0.92 [0.57, 1.49]
3.6 versus mirtazapine	4	766	Odds Ratio (M‐H, Random, 95% CI)	1.52 [1.13, 2.06]
3.7 versus tianeptine	1	44	Odds Ratio (M‐H, Random, 95% CI)	0.66 [0.18, 2.36]
3.8 versus trazodone	1	108	Odds Ratio (M‐H, Random, 95% CI)	1.06 [0.47, 2.38]
3.9 versus venlafaxine	4	807	Odds Ratio (M‐H, Random, 95% CI)	1.57 [1.08, 2.29]