Comparison 8. Standardized mean difference (at 1 ‐ 4 weeks).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Paroxetine versus older ADs	7	723	Std. Mean Difference (IV, Random, 95% CI)	0.19 [‐0.02, 0.39]
1.1 versus amitriptyline	4	566	Std. Mean Difference (IV, Random, 95% CI)	0.14 [‐0.02, 0.31]
1.2 versus clomipramine	1	84	Std. Mean Difference (IV, Random, 95% CI)	‐0.15 [‐0.58, 0.28]
1.3 versus desipramine	1	50	Std. Mean Difference (IV, Random, 95% CI)	0.86 [0.28, 1.44]
1.4 versus imipramine	1	23	Std. Mean Difference (IV, Random, 95% CI)	0.21 [‐0.61, 1.03]
2 Paroxetine versus other SSRIs	1		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
2.1 versus fluoxetine	1	132	Std. Mean Difference (IV, Random, 95% CI)	‐0.03 [‐0.37, 0.32]
3 Paroxetine versus newer or non‐conventional ADs	6		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
3.1 versus aprepitant (MK‐869)	1	121	Std. Mean Difference (IV, Random, 95% CI)	‐0.15 [‐0.50, 0.21]
3.2 versus duloxetine	2	353	Std. Mean Difference (IV, Random, 95% CI)	0.12 [‐0.09, 0.33]
3.3 versus reboxetine	2	805	Std. Mean Difference (IV, Random, 95% CI)	‐0.17 [‐0.31, ‐0.03]
3.4 versus tianeptine	1	246	Std. Mean Difference (IV, Random, 95% CI)	0.13 [‐0.12, 0.38]