Comparison 12. Failure to complete (due to side effects).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Paroxetine versus older ADs	34	5175	Odds Ratio (M‐H, Random, 95% CI)	0.76 [0.63, 0.92]
1.1 versus amitriptyline	12	1698	Odds Ratio (M‐H, Random, 95% CI)	0.74 [0.56, 0.98]
1.2 versus clomipramine	4	1273	Odds Ratio (M‐H, Random, 95% CI)	0.59 [0.41, 0.84]
1.3 versus dothiepin	2	405	Odds Ratio (M‐H, Random, 95% CI)	1.70 [0.78, 3.70]
1.4 versus imipramine	9	1268	Odds Ratio (M‐H, Random, 95% CI)	0.58 [0.43, 0.77]
1.5 versus lofepramine	2	228	Odds Ratio (M‐H, Random, 95% CI)	1.19 [0.45, 3.15]
1.6 versus maprolitine	2	131	Odds Ratio (M‐H, Random, 95% CI)	0.77 [0.01, 70.98]
1.7 versus mianserin	2	92	Odds Ratio (M‐H, Random, 95% CI)	2.26 [0.38, 13.50]
1.8 versus nortriptyline	1	80	Odds Ratio (M‐H, Random, 95% CI)	1.46 [0.43, 4.93]
2 Paroxetine versus other SSRIs	17		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 versus citalopram	1	406	Odds Ratio (M‐H, Random, 95% CI)	1.15 [0.48, 2.78]
2.2 versus escitalopram	2	784	Odds Ratio (M‐H, Random, 95% CI)	1.43 [0.51, 4.00]
2.3 versus fluoxetine	11	2491	Odds Ratio (M‐H, Random, 95% CI)	1.34 [1.06, 1.70]
2.4 versus fluvoxamine	3	261	Odds Ratio (M‐H, Random, 95% CI)	1.16 [0.19, 7.16]
2.5 versus sertraline	1	192	Odds Ratio (M‐H, Random, 95% CI)	1.94 [0.69, 5.48]
3 Paroxetine versus newer or non‐conventional ADs	24		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 versus agomelatine	1	284	Odds Ratio (M‐H, Random, 95% CI)	0.84 [0.34, 2.04]
3.2 versus aprepitant (MK‐869)	1	143	Odds Ratio (M‐H, Random, 95% CI)	1.66 [0.67, 4.13]
3.3 versus bupropion	2	240	Odds Ratio (M‐H, Random, 95% CI)	0.61 [0.24, 1.55]
3.4 versus duloxetine	6	1821	Odds Ratio (M‐H, Random, 95% CI)	0.84 [0.57, 1.25]
3.5 versus hypericum	1	251	Odds Ratio (M‐H, Random, 95% CI)	2.05 [0.60, 6.99]
3.6 versus milnacipran	1	302	Odds Ratio (M‐H, Random, 95% CI)	1.17 [0.59, 2.33]
3.7 versus mirtazapine	3	726	Odds Ratio (M‐H, Random, 95% CI)	1.35 [0.83, 2.21]
3.8 versus reboxetine	3	1375	Odds Ratio (M‐H, Random, 95% CI)	0.38 [0.17, 0.86]
3.9 versus tianeptine	1	327	Odds Ratio (M‐H, Random, 95% CI)	3.38 [1.31, 8.71]
3.10 versus venlafaxine	5	974	Odds Ratio (M‐H, Random, 95% CI)	0.88 [0.50, 1.56]