Comparison 18. SE ‐ Agitation/anxiety.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Paroxetine versus older ADs	15	2240	Odds Ratio (M‐H, Random, 95% CI)	1.12 [0.67, 1.86]
1.1 versus amitriptyline	6	1001	Odds Ratio (M‐H, Random, 95% CI)	1.21 [0.36, 4.03]
1.2 versus clomipramine	1	92	Odds Ratio (M‐H, Random, 95% CI)	0.2 [0.01, 4.28]
1.3 versus dothiepin	1	271	Odds Ratio (M‐H, Random, 95% CI)	2.52 [0.86, 7.35]
1.4 versus imipramine	2	282	Odds Ratio (M‐H, Random, 95% CI)	0.63 [0.18, 2.16]
1.5 versus lofepramine	1	106	Odds Ratio (M‐H, Random, 95% CI)	0.28 [0.01, 7.06]
1.6 versus maprolitine	3	429	Odds Ratio (M‐H, Random, 95% CI)	0.95 [0.38, 2.39]
1.7 versus mianserin	1	59	Odds Ratio (M‐H, Random, 95% CI)	2.0 [0.17, 23.34]
2 Paroxetine versus other SSRIs	8		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 versus fluoxetine	5	713	Odds Ratio (M‐H, Random, 95% CI)	1.15 [0.75, 1.77]
2.2 versus fluvoxamine	1	60	Odds Ratio (M‐H, Random, 95% CI)	2.15 [0.36, 12.76]
2.3 versus sertraline	2	545	Odds Ratio (M‐H, Random, 95% CI)	1.19 [0.66, 2.13]
3 Paroxetine versus newer or non‐conventional ADs	14		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 versus agomelatine	1	284	Odds Ratio (M‐H, Random, 95% CI)	0.74 [0.19, 2.81]
3.2 versus bupropion	2	240	Odds Ratio (M‐H, Random, 95% CI)	0.45 [0.19, 1.08]
3.3 versus duloxetine	4	1095	Odds Ratio (M‐H, Random, 95% CI)	0.82 [0.35, 1.91]
3.4 versus milnacipran	1	302	Odds Ratio (M‐H, Random, 95% CI)	0.73 [0.16, 3.30]
3.5 versus mirtazapine	2	472	Odds Ratio (M‐H, Random, 95% CI)	1.40 [0.63, 3.15]
3.6 versus reboxetine	3	1375	Odds Ratio (M‐H, Random, 95% CI)	0.74 [0.47, 1.17]
3.7 versus tianeptine	1	277	Odds Ratio (M‐H, Random, 95% CI)	0.33 [0.01, 8.14]