Comparison 24. SE ‐ Asthenia.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Paroxetine versus older ADs	17		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 versus amitriptyline	5	779	Odds Ratio (M‐H, Random, 95% CI)	0.44 [0.12, 1.55]
1.2 versus dothiepin	2	405	Odds Ratio (M‐H, Random, 95% CI)	1.58 [0.30, 8.47]
1.3 versus imipramine	6	680	Odds Ratio (M‐H, Random, 95% CI)	1.29 [0.73, 2.28]
1.4 versus lofepramine	1	122	Odds Ratio (M‐H, Random, 95% CI)	4.36 [0.47, 40.16]
1.5 versus maprolitine	3	429	Odds Ratio (M‐H, Random, 95% CI)	0.76 [0.49, 1.16]
2 Paroxetine versus other SSRIs	7		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 versus citalopram	1	406	Odds Ratio (M‐H, Random, 95% CI)	0.59 [0.33, 1.04]
2.2 versus fluoxetine	5	1680	Odds Ratio (M‐H, Random, 95% CI)	1.27 [0.91, 1.77]
2.3 versus fluvoxamine	1	60	Odds Ratio (M‐H, Random, 95% CI)	0.51 [0.13, 1.95]
3 Paroxetine versus newer ADs	13		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 versus aprepitant (MK‐869)	1	143	Odds Ratio (M‐H, Random, 95% CI)	1.47 [0.61, 3.58]
3.2 versus bupropion	1	140	Odds Ratio (M‐H, Random, 95% CI)	4.25 [0.87, 20.80]
3.3 versus duloxetine	3	1006	Odds Ratio (M‐H, Random, 95% CI)	0.79 [0.45, 1.38]
3.4 versus nefazodone	2	246	Odds Ratio (M‐H, Random, 95% CI)	1.15 [0.36, 3.62]
3.5 versus reboxetine	3	1375	Odds Ratio (M‐H, Random, 95% CI)	2.07 [1.19, 3.60]
3.6 versus tianeptine	1	277	Odds Ratio (M‐H, Random, 95% CI)	0.99 [0.06, 16.03]
3.7 versus venlafaxine	1	361	Odds Ratio (M‐H, Random, 95% CI)	0.46 [0.17, 1.23]
3.8 versus trazodone	1	108	Odds Ratio (M‐H, Random, 95% CI)	3.17 [0.13, 79.60]