Javors 2000.

Methods	Six‐week, randomised study.
Participants	Inpatients fulfilling DSM‐IV diagnostic criteria for major depression. Age range: unclear.
Interventions	Paroxetine: 3 participants. Desipramine: 5 participants.. Paroxetine dose range: 30‐60 mg/day. Desipramine dose range: 50‐250 mg/day.
Outcomes	Hamilton rating scale for depression (HDRS); platelet serotonin content.
Notes	The study was primarily designed to assess the reduction of platelet serotonin content in depressed patients treated with paroxetine or desipramine.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "randomly assigned".
Allocation concealment (selection bias)	Unclear risk	No information provided.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No information provided.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No information provided.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No clear information on incomplete outcome data management.
Selective reporting (reporting bias)	High risk	Adverse events, dropouts and side effects were not reported. As dichotomous outcome, only endpoint response rate are reported. (The study was primarily designed to assess the reduction of platelet serotonin content in depressed patients treated with paroxetine or desipramine).
Other bias	Low risk	This study was independent from pharmaceutical industry.