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. Author manuscript; available in PMC: 2023 Apr 12.
Published in final edited form as: Nat Rev Rheumatol. 2012 Oct 23;9(4):252–256. doi: 10.1038/nrrheum.2012.170

Figure 1. The IL-12 cytokine family; their structure and activated signaling pathways.

Figure 1.

IL-12, IL-23, IL-27 and IL-35 are heterodimeric cytokines that belong to IL-12 family. These IL-12 family siblings comprise of both common as well as unique subunits and binding receptors. In addition to their structural relationship, the IL-12 family members activate overlapping JAK/STAT signaling pathways which explains some of their mutual characteristics. IL-12, IL-23 and IL-27 structure, expression and mechanism of action is well studied and our knowledge about IL-35 is rapidly growing.

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