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. 2023 Mar 21;13(6):1974–2014. doi: 10.7150/thno.80887

Figure 9.

Figure 9

(A) a) Schematic illustration for the synthesis of UMNOCC-PEG. b) Scheme of the tumor theranostic application and (c) therapeutic mechanism of UMNOCC-PEG for the improvement of PDT induced by NIR, Cu2+-initiated CDT and gas therapy. (B) a) Schematic illustration of NO release from UMNOCC-PEG. b) Cumulative Cu release and c) quantitative assessment of NO generation from UMNOCC-PEG under different pH conditions. (C) a) The cell viabilities of L929 fibroblast cells upon incubation with UMNOCC-PEG for 12 h and 24 h. b) The cell viabilities of HeLa cells after being treated under different conditions. c) γ-H2AX-stained HeLa cells treated with PBS and UMNOCC-PEG (0.5 W/cm2, 500 μg/mL). Scale bar: 50 μm. d) CLSM images of HeLa cells co-stained with calcein AM (live cells, green) and propidium iodide (dead cells, red) after being treated under different conditions (0.5 W/cm2, 500 μg/mL). Scale bar: 50 μm. Reproduced with permission 187. Copyright 2020, The Royal Society of Chemistry.