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. 2023 Mar 21;13(6):1826–1842. doi: 10.7150/thno.82069

Figure 3.

Figure 3

DON ameliorates lung fibrosis in BLM-induced mice by inhibiting fibroblast activation. A. Representative immunofluorescent staining with αSMA for lung tissue (×200 magnification). B. Representative protein levels in lung tissue. C~E. Statistical analysis of the levels of collagen I, collagen III, and αSMA in lung tissue (n = 8). F. Representative protein levels in lung fibroblasts. G~I. Quantitative analysis of the levels of collagen I, collagen III, and αSMA in lung fibroblasts (n = 4). J: Representative immunofluorescent staining with collagen I and αSMA for fibroblasts (×200 magnification). αSMA: alpha-smooth muscle actin, BLM: bleomycin, Ctrl: control, Col1: collagen I, Col3: collagen III, DON: donepezil. *P < 0.05, versus Ctrl group, #P < 0.05, versus BLM group.