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. 2023 Mar 21;13(6):1826–1842. doi: 10.7150/thno.82069

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DON reduces the Th17-mediated inflammatory response in BLM‑induced mice model. A. Representative immunohistochemical staining for CD68 and CD3 (×400 magnification, image size: 715 × 408 μm). B~C. Quantitative analysis of the CD68 and CD3 positive rate. D. The abundance of 24 types of immune cell infiltrating in lung tissue of non-PH and PH patients. E. Boxplot of the proportion of 24 types of immune cells. F. GO analysis indicating the major significant biological processes, includes negative regulation of Th17 cell lineage commitment. G. The original flow cytometry plots. H. Quantitative analysis the percentage of CD4⁺ T lymphocytes in lung tissue. I. Quantitative analysis the percentage of Th17 cells in lung tissue. Ctrl: control, BLM: bleomycin, DON: donepezil, GO: gene ontology, IL17A: interleukin 17A, Th17: T helper 17. *P < 0.05, versus Ctrl group, ^#P < 0.05, versus BLM group, (n = 6).