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. 2023 Mar 21;13(6):1906–1920. doi: 10.7150/thno.83912

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In vitro construction and characterization of TME and reduction dual responsive polymersomal prodrug (TRPP) nanoplatform and ^DPPA-1 decorated TRPP (^DPPA-TRPP). (A) Schematic illustration of preparation, pH and ROS responsiveness of ^DPPA-TRPP. (B) UV-vis spectrum of prodrug copolymer. Inset image presented tri-block or prodrug copolymer. (C) In vitro H₂O₂ (100 µM) consumption mediated by prodrug copolymer. (D) Size and morphology of TRPP measured by DLS and TEM, respectively. (E) ^DPPA-TRPP characterization by DLS and TEM. (F) Morphology transformation of ^DPPA-TRPP from polymersomes into micelles at pH 6.8 characterized by HAADF-STEM. Result at 0h represented the HAADF-STEM image of ^DPPA-TRPP. Result at 24h represented the STEM-EDC mapping images of ^DPPA-RMP. (G) ^DPPA-1 shedding from ^DPPA-TRPP in the condition of H₂O₂ (100 µM) detected by HPLC. (H) In vitro DOX release from ^DPPA-TRPP under different conditions within 24 h measured by fluorescence spectrophotometer. (n = 3, mean ± SD). (I) In vitro Tab release from ^DPPA-TRPP under different conditions within 24 h detected by LC-MS (n = 3, mean ± SD).