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. 2023 Mar 21;13(6):1906–1920. doi: 10.7150/thno.83912

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Cellular behavior and in vivo tumor accumulation investigation. (A) Cellular internalization of ^DPPA-TRPP in 4T1 cells characterized by CLSM and (B) flow cytometry, respectively. (C) ^DPPA-TRPP mediated ICD via CRT exposure and HMGB1 release via CLSM characterization. Blue color presented DAPI. Green and red colors were CRT and HMGB1, respectively. (D) TRPP induced ICD by flow cytometry characterization. (E) In vivo tumor accumulation of ^DPPA-TRPP/DIR and TRPP/DIR at different time points.