FIGURE 1.

Effects on haemodynamics and activity. Mean arterial pressure (MAP; a), ΔMAP (b), heart rate (c) and locomotor activity (d) in diabetic Ren2 rats treated with either vehicle, valsartan, captopril, angiotensinogen (AGT) small interfering RNA (siRNA), AGT siRNA + valsartan, or captopril + valsartan for 3 weeks. Treatment was started 15 weeks after the induction of diabetes. Days −3 to 0 correspond to the period immediately before treatment. Data are mean ± SEM of n = 7–9. *P < 0.05 versus vehicle.