FIGURE 2.

Effects on the circulating renin‐angiotensin system. Angiotensinogen (AGT; a), renin (b), prorenin (c), angiotensin I (Ang I; d), angiotensin II (e) and aldosterone (f) in blood plasma of diabetic Ren2 rats treated with either vehicle, valsartan, captopril, AGT small interfering RNA (siRNA), AGT siRNA + valsartan, or captopril + valsartan for 3 weeks. Treatment was started 15 weeks after the induction of diabetes. Data are mean ± SEM of n = 7–9. NS, not significant; *P < 0.05 versus vehicle.