Table 1.
Case | Donor age (years) | Sex | BMI (kg/m2) | Smoker | Diabetes | HTN | HL | Functional WIT (min) | Asystolic WIT (min) | Time on OCS (min) | Fluoro time (s) | Angiographic findings | Outcome |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Case series | |||||||||||||
1 | 49 | M | 26.3 | Yes | No | Yes | No | NR | NR | 319 | 438 | Severe multivessel disease | Unsuitable (DBD research run) |
2 | 58 | M | 25.7 | No | No | No | Yes | NR | NR | 265 | NR | Mild (<30%) atherosclerosis | Transplanted (DBD) |
3 | 54 | M | 32 | No | No | Yes | Yes | 21 | 14 | 276 | 259 | Mild (<30%) atherosclerosis | Transplanted |
4 | 51 | M | 29.4 | No | No | Yes | Yes | 26 | 14 | 205 | 535 | Mild (<30%) atherosclerosis | Unsuitable on clinical grounds |
5 | 53 | F | 26 | No | No | No | Yes | 23 | 11 | 241 | NR | Minimal (<10%) atherosclerosis; separate origins of the LAD and LCx | Transplanted |
6 | 49 | M | 29.4 | Yes | No | Yes | No | 13 | 10 | 296 | 135 | Mild (<30%) atherosclerosis | Transplanted |
7 | 42 | M | 29.4 | Yes | No | No | No | 21 | 14 | 160 | 186 | Mild (<30%) atherosclerosis | Transplanted |
8 | 53 | F | 46.1 | Yes | Yes | Yes | Yes | 24 | 14 | 285 | 216 | Mild (<30%) atherosclerosis | Transplanted |
Literature search | |||||||||||||
Shibilsky et al. 10 | NA | NR | Porcine model—moderate LAD stenosis; IVUS feasible | NA | |||||||||
Ghodisizad et al. 8 | 46 | M | 24 | NR | 37 | 570 | NR | Minor diffuse atherosclerosis | Unsuitable due to haemodynamic parameters |
Note: aWIT is the time from cessation of circulation in the donor to delivery of preservation flush to the donor heart, >15 min is a predictor for severe primary graft dysfunction and perioperative ECMO. Functional WIT, functional warm ischemic time is the time from systolic of <90 mmHg in the donor to delivery of preservation flush to the donor heart, an upper limit of 30 min is permitted for this timeframe.
Abbreviations: CVD, cardiovascular disease; ECMO, extra corporeal membrane oxygenation; HL, hyperlipidaemia; HTN, hypertension; IVUS, intravascular ultrasound; LAD, left anterior descending artery; LCx, left circumflex coronary artery; OCS, organ care system; NR, not reported/recorded.