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. 2022 Oct 11;180(2):174–193. doi: 10.1111/bph.15947

FIGURE 2.

FIGURE 2

KV7 channel modulators are more efficacious and potent on arteries from female D/M, when compared with female P/E Wistar rats. Mean data of relaxation of pre‐contracted tone (U46619; 300 nmol·L−1) in response to ML213 (0.01–10 μmol·L−1) in renal (n = 5–6; a) and mesenteric (n = 5–6; b) arteries from female pro‐oestrus/oestrus (P/E) and female di‐oestrus/met‐oestrus (D/M) rats. Mean data of increases in basal tone in response to solvent control (DMSO), linopirdine (10 μmol·L−1) and HMR‐1556 (10 μmol·L−1) in renal (n = 10–12; c) and mesenteric arteries (n = 10–13; d). Representative traces of contraction of renal arteries from female P/E and female D/M rats in response to pan‐KV7 channel blocker linopirdine (10 μmol·L−1; e). Data shown are means ± SEM; n = number of animals used. *P ≤ 0.05, significantly different from female D/M rats; two‐way ANOVA with post hoc Bonferroni (a, b) or Dunnett (c, d) correction.