FIGURE 4.

GO terms and KEGG pathway analysis of the promoter DMR‐related genes DMRs in IL and SNL. (a) Enriched GO terms of promoter hypermethylated DMR‐related genes in IL compared with SNL. (b) Enriched GO terms of promoter hypomethylated DMR‐related genes in IL compared with SNL. The ordinate was the enriched GO term, and the abscissa was the number of DMR‐related genes in the term (*p value ≤ .05). (c) Enriched pathways of promoter hypermethylated DMR‐related genes in IL compared with SNL. (d) Enriched pathways of promoter hypomethylated DMR‐related genes in IL compared with SNL. Size and color of the bubble represented the amount of DMR‐related gene enriched in the pathway and enrichment significance, respectively. (e) The comparison of differentially expressed genes (DEGs) and promoter hyper/hypomethylated genes between IL and SNL samples. Left: The intersection of promoter DMR‐related genes and DEGs. Middle: Bar plots displaying the representative GO terms enriched in 20 coincident genes. Right: Candidate gene results. Shown are genes enriched in NSCLP‐related GO pathways. DMR, differentially methylated region; Gene Ontology; IL, injured lip; KEGG, Kyoto Encyclopedia of Genes and Genomes; NSCLP, nonsyndromic cleft lip and palate; SNL, self‐normal lip