TABLE 1.
Participant demographics and baseline characteristics
| Marstacimab dose group | |||||||
|---|---|---|---|---|---|---|---|
| Cohort 1 | Cohort 2 | Cohort 3 | Cohort 4 | Cohort 6 | Total 300 mg (n = 10) | Total 300‐mg loading + 150 mg (n = 10) | |
| Parameter | 300 mg → 300 mg without inhibitors (n = 5) | 300‐mg loading + 150 mg → 300‐mg loading + 150 mg without inhibitors (n = 4) | 450 mg → 300‐mg loading + 150 mg without inhibitors (n = 4) | 300 mg → 300 mg with inhibitors (n = 5) | De novo 300‐mg loading + 150 mg with inhibitors (n = 2) | ||
| Age, years | |||||||
| Mean (SD) | 33.0 (9.7) | 31.3 (10.6) | 41.8 (16.2) | 42.0 (5.2) | 20.0 (1.4) | 37.5 (8.8) | 33.2 (14.1) |
| Median (range) | 28.0 (27–50) | 29.5 (22–44) | 45.5 (19–57) | 40.0 (37–49) | 20.0 (19–21) | 37.5 (27–50) | 29.5 (19–57) |
| 18–44, n (%) | 4 (80.0) | 4 (100.0) | 2 (50.0) | 3 (60.0) | 2 (100.0) | 7 (70.0) | 8 (80.0) |
| 45–64, n (%) | 1 (20.0) | 0 | 2 (50.0) | 2 (40.0) | 0 | 3 (30.0) | 2 (20.0) |
| Race, n (%) | |||||||
| White | 3 (60.0) | 2 (50.0) | 4 (100.0) | 3 (60.0) | 2 (100.0) | 6 (60.0) | 8 (80.0) |
| Black | 2 (40.0) | 2 (50.0) | 0 | 2 (40.0) | 0 | 4 (40.0) | 2 (20.0) |
| Ethnicity, n (%) | |||||||
| Hispanic or Latino | 3 (60.0) | 2 (50.0) | 1 (25.0) | 1 (20.0) | 0 | 4 (40.0) | 3 (30.0) |
| Not Hispanic or Latino | 2 (40.0) | 2 (50.0) | 3 (75.0) | 4 (80.0) | 2 (100.0) | 6 (60.0) | 7 (70.0) |
| Height, cm, mean (SD) | — | — | — | — | 179.5 (0.7) | — | 179.5 (0.7) |
| Weight, kg, mean (SD) | 73.8 (15.6) | 63.2 (11.3) | 86.7 a | 82.1 (12.0) | 66.6 (12.0) | 77.5 (13.9) | 67.5 (12.7) |
| BMI, kg/m2, mean (SD) | — | — | — | — | 20.7 (3.9) | — | 20.7 (3.9) |
| Type of haemophilia, n (%) | |||||||
| Haemophilia A | 5 (100.0) | 3 (75.0) | 4 (100.0) | 5 (100.0) | 2 (100.0) | 10 (100.0) | 9 (90.0) |
| Haemophilia B | 0 | 1(25.0) | 0 | 0 | 0 | 0 | 1 (10.0) |
| Haemophilic arthropathy, n (%) | 5 (100.0) | 2 (50.0) | 1 (25.0) | 3 (60.0) | 2 (100.0) | 8 (80.0) | 5 (50.0) |
| Target joints, n (%) | 5 (100.0) | 2 (50.0) | 1 (25.0) | 3 (60.0) | 2 (100.0) | 8 (80.0) | 5 (50.0) |
Abbreviations: BMI, body mass index; SD, standard deviation.
a
SD not available.